NAME of the study: BISCOTE (Bacteria Isolation from Stools Collected from Centenarians People)
Sponsor : BIOASTER
Collaborator: Gerond’if (Gérontopole d’Ile de France)
Main investigator: Pr Olivier HANON
Brief Summary:
The compositional analysis of commensal bacterial populations collected from a variety of clinical samples has been recently made possible with the availability of Next Generation Sequencing (NGS) technologies. The term ‘next-generation probiotics’ (NGP) is now widely used to describe these commensal species of potential health interest. However, this approach is still hampered by the fact that there are usually few or even no strains available for a number of commensal species. In this context, BIOASTER has developed a specific technological process based on flow cytometry analysis with sorting under strictly anaerobic conditions to target and cultivate commensal species of interest.
The review of the literature shows that certain species present among centenarians have an interest in maintaining the longevity of these individuals. Numerous studies have shown that the intestinal microbiota of centenarians presents a greater diversity compared to groups of younger subjects as well as an enrichment in certain bacteria such as Akkermansia and Christensenella.
The goal of this observational study is to constitute a biological samples collection from centenarian people, to proceed with the isolation of beneficial commensal strains such as Faecalibacterium prausnitzii, Akkermansia muciniphila and Oscillospiraceae, in a non-limitative way.
Target population: Old people > 95 years old will be recruited within the EHPAD network of the Gerontopole of “Ile de France” network.
Methodology: Non-interventional research. Realization of biological samples (Stools in anaerobic conditions, Blood and TruCultures tubes) for each volunteer.
- Isolation of bacterial strains of interest
- Healthy aging
Deployment schedule: Start of inclusions on 06/06/2023.
Duration of recruitment = 6 months
More information on Clinicaltrials.gov (english only)
Contact BIOASTER Clinical Operations: recherche-clinique@bioaster.org